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Inositol phosphate metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
H+ + D-myo-Inositol_1-phosphate + CTP <=> CDP-1L-myo-inositol + diphosphate 2.7.7.74 1L-myo-inositol 1-phosphate cytidylyltransferase

phosphatidylinositol_4,5-bisphosphate + ATP <=> phosphatidylinositol_3,4,5-trisphosphate + ADP + H+ 2.7.1.137 phosphatidylinositol 3-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase



D-myo-Inositol_1-phosphate + H2O <=> myo-inositol + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.93 L-galactose 1-phosphate phosphatase







phosphatidylinositol + ATP <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + ADP + H+ 2.7.1.137 phosphatidylinositol 3-kinase
2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase




D-myo-inositol_(1,4)-bisphosphate + H2O <=> phosphate + Inositol_4-phosphate 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase


inositol_1,3,4-trisphosphate + H2O <=> D-myo-Inositol_3,4-bisphosphate + phosphate 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase



5-dehydro-2-deoxy-D-gluconate + ATP <=> H+ + 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP 2.7.1.92 5-dehydro-2-deoxygluconokinase

inositol_3,4,5,6-tetrakisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate + ADP 2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase
2.7.4.21 inositol-hexakisphosphate kinase




1-phosphatidyl-1D-myo-inositol_4-phosphate + ATP <=> phosphatidylinositol_4,5-bisphosphate + ADP + H+ 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase




inositol_1,3,4-trisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5-tetrakisphosphate + ADP 2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase


3-Dehydro-scyllo-inosose + H2O <=> 5-Dehydro-L-gluconate + H+ 3.7.1

1D-myo-inositol_1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol_1,4,5-trisphosphate + phosphate 3.1.3.62 multiple inositol-polyphosphate phosphatase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase


inositol_1,3,4-trisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,6-tetrakisphosphate + ADP 2.7.1.127 inositol-trisphosphate 3-kinase
2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase



1D-myo-inositol_1,3,4,5-tetrakisphosphate + H2O <=> inositol_1,3,4-trisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase


1-phosphatidyl-1D-myo-inositol_4-phosphate + ATP <=> 1-phosphatidyl-1D-myo-inositol_3,4-bisphosphate + ADP + H+ 2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase

5-Dehydro-L-gluconate <=> D-tagaturonate 5.1
5.3.3


1-phosphatidyl-1D-myo-inositol_3,5-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase




myo-inositol_hexakisphosphate + H2O <=> D-myo-inositol_(1,2,3,4,5)-pentakisphosphate + phosphate 3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.62 multiple inositol-polyphosphate phosphatase



1D-myo-inositol_1,4,5-trisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5-tetrakisphosphate + ADP 2.7.1.127 inositol-trisphosphate 3-kinase
2.7.1.140 inositol-tetrakisphosphate 5-kinase
2.7.1.151 inositol-polyphosphate multikinase



scyllo-Inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.370 scyllo-inositol 2-dehydrogenase (NAD+)


5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate 5.3.1.30 5-deoxy-glucuronate isomerase

scyllo-inosose + NAD+ <=> 3-Dehydro-scyllo-inosose + NADH + H+ 1.1.1

malonate_semialdehyde + CoA + NADP+ <=> acetyl-CoA + CO2 + NADPH 1.2.1
1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)


myo-inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.114 apiose 1-reductase
1.1.1.18 inositol 2-dehydrogenase


1-phosphatidyl-1D-myo-inositol_3,4-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase

D-glucose_6-phosphate <=> D-myo-Inositol_1-phosphate 5.5.1.4 inositol-3-phosphate synthase

phosphatidylinositol_4,5-bisphosphate + H2O <=> diacylglycerol + 1D-myo-inositol_1,4,5-trisphosphate + H+ 3.1.4.11 phosphoinositide phospholipase C
3.1.4.3 phospholipase C


phosphatidylinositol_3,4,5-trisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_3,4-bisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase


scyllo-Inositol + NADP+ <=> scyllo-inosose + NADPH + H+ 1.1.1
1.1.1.371 scyllo-inositol 2-dehydrogenase (NADP+)


myo-inositol_hexakisphosphate + H2O <=> 1D-myo-inositol_1,2,4,5,6-pentakisphosphate + phosphate 3.1.3.10 glucose-1-phosphatase
3.1.3.26 4-phytase
3.1.3.62 multiple inositol-polyphosphate phosphatase
3.1.3.72 5-phytase
3.1.3.8 3-phytase





H2O + 1D-myo-inositol_1,4,5-trisphosphate <=> D-myo-inositol_(1,4)-bisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase


Inositol_4-phosphate + H2O <=> myo-inositol + phosphate 3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase


1-phosphatidyl-1D-myo-inositol_5-phosphate + 2 ATP <=> phosphatidylinositol_3,4,5-trisphosphate + 2 ADP not assigned

D-chiro-Inositol + NAD+ <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.369 D-chiro-inositol 1-dehydrogenase


S-adenosyl-L-methionine + myo-inositol <=> H+ + S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol 2.1.1.39 inositol 3-methyltransferase

inositol_3,4,5,6-tetrakisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate + ADP 2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase
2.7.4.21 inositol-hexakisphosphate kinase




1-phosphatidyl-1D-myo-inositol_4-phosphate + H2O <=> phosphatidylinositol + phosphate 3.1.3
3.1.3.25 inositol-phosphate phosphatase
3.1.3.78 phosphatidylinositol-4,5-bisphosphate 4-phosphatase
3.1.3.B4




phosphatidylinositol_3,4,5-trisphosphate + H2O <=> phosphatidylinositol_4,5-bisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase


1-phosphatidyl-1D-myo-inositol_5-phosphate + ATP <=> 1-phosphatidyl-1D-myo-inositol_3,5-bisphosphate + ADP + H+ 2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase

S-adenosyl-L-methionine + myo-inositol <=> H+ + S-adenosyl-L-homocysteine + D-bornesitol 2.1.1.40 inositol 1-methyltransferase

Inositol_1,3-bisphosphate + H2O <=> D-myo-Inositol_1-phosphate + phosphate 3.1.3.64 phosphatidylinositol-3-phosphatase

1-phosphatidyl-1D-myo-inositol_5-phosphate + ATP <=> phosphatidylinositol_4,5-bisphosphate + ADP + H+ 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase


3D-3,5/4-trihydroxycyclohexa-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+ 3.7.1.22 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening)

malonate_semialdehyde + CoA + NAD+ <=> acetyl-CoA + CO2 + NADH 1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)


1-phosphatidyl-1D-myo-inositol_3,5-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase




phosphatidylinositol + H2O <=> diacylglycerol + D-myo-Inositol_1-phosphate + H+ 3.1.4.11 phosphoinositide phospholipase C
3.1.4.3 phospholipase C
3.1.4.50 glycosylphosphatidylinositol phospholipase D
4.6.1.13 phosphatidylinositol diacylglycerol-lyase




phosphatidylinositol_4,5-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_4-phosphate + phosphate 3.1.3.25 inositol-phosphate phosphatase
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase




ATP + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate <=> ADP + myo-inositol_hexakisphosphate + H+ 2.7.1.151 inositol-polyphosphate multikinase
2.7.1.158 inositol-pentakisphosphate 2-kinase


scyllo-inosose <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone 5.3.99.11 2-keto-myo-inositol isomerase

1-phosphatidyl-1D-myo-inositol_5-phosphate + H2O <=> phosphatidylinositol + phosphate 3.1.3
3.1.3.64 phosphatidylinositol-3-phosphatase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
3.1.3.78 phosphatidylinositol-4,5-bisphosphate 4-phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase





scyllo-inosose <=> H2O + 3D-3,5/4-trihydroxycyclohexa-1,2-dione 4.2.1.44 myo-inosose-2 dehydratase

myo-inositol + ATP <=> H+ + D-myo-Inositol_1-phosphate + ADP 2.7.1.64 inositol 3-kinase

myo-inositol + O2 <=> D-glucuronate + H2O 1.13.99.1 inositol oxygenase

1D-myo-inositol_1,4,5-trisphosphate + ATP <=> H+ + 1D-myo-inositol_1,4,5,6-tetrakisphosphate + ADP 2.7.1.151 inositol-polyphosphate multikinase

CDP-1L-myo-inositol + D-myo-Inositol_1-phosphate <=> H+ + CMP + bis(1L-myo-inositol)_3,1''-phosphate_1-phosphate 2.7.8.34 CDP-L-myo-inositol myo-inositolphosphotransferase

1D-myo-inositol_1,3,4,6-tetrakisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate + ADP 2.7.1.140 inositol-tetrakisphosphate 5-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase



6-phospho-5-dehydro-2-deoxy-D-gluconate <=> malonate_semialdehyde + dihydroxyacetone_phosphate 4.1.2.29 5-dehydro-2-deoxyphosphogluconate aldolase

D-glyceraldehyde_3-phosphate <=> dihydroxyacetone_phosphate 5.3.1.1 triose-phosphate isomerase

CDP-diacylglycerol + myo-inositol <=> phosphatidylinositol + CMP + H+ 2.7.8.11 CDP-diacylglycerol---inositol 3-phosphatidyltransferase

D-myo-Inositol_3,4-bisphosphate + H2O <=> D-myo-Inositol_1-phosphate + phosphate 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase

phosphatidylinositol + ATP <=> 1-phosphatidyl-1D-myo-inositol_4-phosphate + ADP + H+ 2.7.1.67 1-phosphatidylinositol 4-kinase

D-myo-Inositol_1-phosphate + H2O <=> myo-inositol + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.93 L-galactose 1-phosphate phosphatase







Visualization of the pathway